From: T cell receptor-engineered T cells for leukemia immunotherapy
Strategies | Research references |
---|---|
Editing TCRs | |
Generating dominant TCR constructs that can inhibited the endogenous TCRs | [15] |
Promoting the disruption of the endogenous TCRs | [32] |
Disrupting only the endogenous TCR α chain | [33] |
Silenced endogenous TCR genes | [34] |
Knockout endogenous TCRβ simultaneously transduction of transferred TCRs | [35] |
Using different kinds of cells | |
γδT cells | [36] |
CD4+ and CD8+ T cells without endogenous αβ TCRs | [35] |
Hematopoietic stem cells | [37] |
Reprogrammed T cells | [38] |