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Table 2 The strategies for avoiding transferred TCR mispairing with endogenous TCRs

From: T cell receptor-engineered T cells for leukemia immunotherapy

Strategies

Research references

Editing TCRs

 

 Generating dominant TCR constructs that can inhibited the endogenous TCRs

[15]

 Promoting the disruption of the endogenous TCRs

[32]

 Disrupting only the endogenous TCR α chain

[33]

 Silenced endogenous TCR genes

[34]

 Knockout endogenous TCRβ simultaneously transduction of transferred TCRs

[35]

Using different kinds of cells

 

 γδT cells

[36]

 CD4+ and CD8+ T cells without endogenous αβ TCRs

[35]

 Hematopoietic stem cells

[37]

 Reprogrammed T cells

[38]