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Table 2 Univariate analysis of clinical features and risk score

From: Identification of a 6-gene signature predicting prognosis for colorectal cancer

Variables Group Colorectal cancer COAD READ
Number HR (95% CI) P value Number HR (95% CI) P value Number HR (95% CI) P value
Age ≤ 67/> 67 282/280 1.03 (1.01–1.04) 7.99E−04 197/222 1.02 (1.00–1.04) 4.20E−02 85/58 1.09 (1.04–1.14) 2.68E−04
Gender Female/male 256/306 1.11 (0.77–1.62) 5.69E−01 194/225 1.17 (0.77–1.78) 4.68E−01 62/81 0.98 (0.43–2.20) 9.54E−01
New tumor after initial treatment No/yes 402/110 2.52 (1.70–3.74) 4.26E−06 299/81 2.53 (1.63–3.93) 3.86E−05 103/29 2.53 (1.04–6.15) 4.03E−02
History of colon polyps No/yes 324/154 0.80 (0.48–1.33) 3.84E−01 229/124 0.76 (0.43–1.35) 3.43E−01 95/30 0.98 (0.32–2.96) 9.73E−01
Residual tumor No/yes 407/30 3.96 (2.26–6.96) 1.65E−06 302/20 3.81 (1.89–7.68) 1.81E−04 105/10 3.38 (1.23–9.28) 1.79E−02
Pathologic stage I–II/III–IV 299/243 3.17 (2.09–4.79) 4.83E−08 231/177 3.07 (1.95–4.85) 1.41E−06 68/66 3.72 (1.35–10.26) 1.10E−02
Stage M M0/M1 415/76 4.51 (2.95–6.89) 3.92E−12 309/55 4.69 (2.87–7.66) 6.55E−10 106/21 4.05 (1.70–9.68) 1.62E−03
Stage N N0/N1–2 315/244 2.90 (1.96–4.30) 1.04E−07 244/175 2.86 (1.85–4.42) 2.21E−06 71/69 3.24 (1.27–8.29) 1.39E−02
Stage T T1–2/T3–4 116/445 2.18 (1.13–4.18) 1.94E−02 86/333 2.87 (1.25–6.59) 1.30E−02 30/112 1.20 (0.41–3.57) 7.38E−01
Tumor tissue site Colon/rectum 419/143 0.87 (0.55–1.36) 5.34E−01
Risk score Low/high 281/281 3.08 (2.03–4.69) 1.36E−07 210/209 2.9 (1.82–4.62) 7.31E−06 71/72 4.34 (1.62–11.64) 3.57E−03
  1. HR hazard ratio, CI confidence interval, COAD colon adenocarcinoma, READ rectum adenocarcinoma, M metastasis, N node, T tumor