Table 2 Univariate analysis of clinical features and risk score
From: Identification of a 6-gene signature predicting prognosis for colorectal cancer
Variables | Group | Colorectal cancer | COAD | READ | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Number | HR (95% CI) | P value | Number | HR (95% CI) | P value | Number | HR (95% CI) | P value | ||
Age | ≤ 67/> 67 | 282/280 | 1.03 (1.01–1.04) | 7.99E−04 | 197/222 | 1.02 (1.00–1.04) | 4.20E−02 | 85/58 | 1.09 (1.04–1.14) | 2.68E−04 |
Gender | Female/male | 256/306 | 1.11 (0.77–1.62) | 5.69E−01 | 194/225 | 1.17 (0.77–1.78) | 4.68E−01 | 62/81 | 0.98 (0.43–2.20) | 9.54E−01 |
New tumor after initial treatment | No/yes | 402/110 | 2.52 (1.70–3.74) | 4.26E−06 | 299/81 | 2.53 (1.63–3.93) | 3.86E−05 | 103/29 | 2.53 (1.04–6.15) | 4.03E−02 |
History of colon polyps | No/yes | 324/154 | 0.80 (0.48–1.33) | 3.84E−01 | 229/124 | 0.76 (0.43–1.35) | 3.43E−01 | 95/30 | 0.98 (0.32–2.96) | 9.73E−01 |
Residual tumor | No/yes | 407/30 | 3.96 (2.26–6.96) | 1.65E−06 | 302/20 | 3.81 (1.89–7.68) | 1.81E−04 | 105/10 | 3.38 (1.23–9.28) | 1.79E−02 |
Pathologic stage | I–II/III–IV | 299/243 | 3.17 (2.09–4.79) | 4.83E−08 | 231/177 | 3.07 (1.95–4.85) | 1.41E−06 | 68/66 | 3.72 (1.35–10.26) | 1.10E−02 |
Stage M | M0/M1 | 415/76 | 4.51 (2.95–6.89) | 3.92E−12 | 309/55 | 4.69 (2.87–7.66) | 6.55E−10 | 106/21 | 4.05 (1.70–9.68) | 1.62E−03 |
Stage N | N0/N1–2 | 315/244 | 2.90 (1.96–4.30) | 1.04E−07 | 244/175 | 2.86 (1.85–4.42) | 2.21E−06 | 71/69 | 3.24 (1.27–8.29) | 1.39E−02 |
Stage T | T1–2/T3–4 | 116/445 | 2.18 (1.13–4.18) | 1.94E−02 | 86/333 | 2.87 (1.25–6.59) | 1.30E−02 | 30/112 | 1.20 (0.41–3.57) | 7.38E−01 |
Tumor tissue site | Colon/rectum | 419/143 | 0.87 (0.55–1.36) | 5.34E−01 | – | – | – | – | – | – |
Risk score | Low/high | 281/281 | 3.08 (2.03–4.69) | 1.36E−07 | 210/209 | 2.9 (1.82–4.62) | 7.31E−06 | 71/72 | 4.34 (1.62–11.64) | 3.57E−03 |