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Table 5 The associations between ESR1 rs2881766 and clinicopathological features of breast cancer

From: Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women

Variables

Genotype

OR (95% CI)

TT

GT

GG

GG vs.TT

GT vs.TT

GT/GG vs.TT

GG vs. TT/GT

Tumor size (cm)

< 2

55

72

25

    

≥ 2

118

146

43

0.80 (0.45–1.44)

0.95 (0.62–1.45)

0.91 (0.61–1.36)

0.83 (0.48–1.41)

LN metastasis

No

60

88

36

    

Yes

113

130

32

0.47 (0.27–0.83)

0.78 (0.52–1.19)

0.69 (0.47–1.03)

0.54 (0.32–0.91)

Histological grade

SBR 1–2

89

117

38

    

SBR 3

84

101

30

0.84 (0.48–1.47)

0.91 (0.61–1.36)

0.90 (0.61–1.31)

0.88 (0.52–1.48)

Venous invasion

None–little

106

140

46

    

Moderate-severe

67

78

22

0.76 (0.42–1.37)

0.88 (0.58–1.33)

0.85 (0.58–1.26)

0.81 (0.47–1.40)

ER

(−)

71

92

39

    

(+)

102

126

29

0.52 (0.29–0.91)

0.95 (0.64–1.43)

0.82 (0.56–1.21)

0.53 (0.32–0.90)

PR

(−)

75

100

33

    

(+)

98

118

35

0.81 (0.46–1.42)

0.90 (0.60–1.35)

0.88 (0.60–1.29)

0.86 (0.51–1.44)

Her-2

(−)

128

155

47

    

(+)

45

63

21

1.27 (0.69–2.35)

1.16 (0.74–1.81)

1.18 (0.77–1.81)

1.17 (0.67–2.05)

Ki–67 (%)

< 14

109

140

45

    

≥ 14

64

78

23

0.87 (0.48–1.57)

0.95 (0.63–1.44)

0.93 (0.63–1.38)

0.90 (0.52–1.54)

  1. The significant ORs and 95%CIs were presented in italic
  2. LN lymph node, ER estrogen receptor, PR progesterone receptor, Her-2 human epidermal growth factor receptor 2, SBR Scarff, Bloom and Richardson tumor grade, OR odds ratio, 95% CI confidence interval
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Cancer Cell International

ISSN: 1475-2867

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