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Table 5 The associations between ESR1 rs2881766 and clinicopathological features of breast cancer

From: Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women

Variables Genotype OR (95% CI)
TT GT GG GG vs.TT GT vs.TT GT/GG vs.TT GG vs. TT/GT
Tumor size (cm)
< 2 55 72 25     
≥ 2 118 146 43 0.80 (0.45–1.44) 0.95 (0.62–1.45) 0.91 (0.61–1.36) 0.83 (0.48–1.41)
LN metastasis
No 60 88 36     
Yes 113 130 32 0.47 (0.27–0.83) 0.78 (0.52–1.19) 0.69 (0.47–1.03) 0.54 (0.32–0.91)
Histological grade
SBR 1–2 89 117 38     
SBR 3 84 101 30 0.84 (0.48–1.47) 0.91 (0.61–1.36) 0.90 (0.61–1.31) 0.88 (0.52–1.48)
Venous invasion
None–little 106 140 46     
Moderate-severe 67 78 22 0.76 (0.42–1.37) 0.88 (0.58–1.33) 0.85 (0.58–1.26) 0.81 (0.47–1.40)
ER
(−) 71 92 39     
(+) 102 126 29 0.52 (0.29–0.91) 0.95 (0.64–1.43) 0.82 (0.56–1.21) 0.53 (0.32–0.90)
PR
(−) 75 100 33     
(+) 98 118 35 0.81 (0.46–1.42) 0.90 (0.60–1.35) 0.88 (0.60–1.29) 0.86 (0.51–1.44)
Her-2
(−) 128 155 47     
(+) 45 63 21 1.27 (0.69–2.35) 1.16 (0.74–1.81) 1.18 (0.77–1.81) 1.17 (0.67–2.05)
Ki–67 (%)
< 14 109 140 45     
≥ 14 64 78 23 0.87 (0.48–1.57) 0.95 (0.63–1.44) 0.93 (0.63–1.38) 0.90 (0.52–1.54)
  1. The significant ORs and 95%CIs were presented in italic
  2. LN lymph node, ER estrogen receptor, PR progesterone receptor, Her-2 human epidermal growth factor receptor 2, SBR Scarff, Bloom and Richardson tumor grade, OR odds ratio, 95% CI confidence interval