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Table 4 Effective drugs for the reduction of HPRT1

From: Potential new biomarkers for endometrial cancer

Cell line Drug Inhibition target Target symbol PTEZ score
Drugs with significant reduction in HPRT1 expression post treatment
 HT29 AS-703026 Mitogen-activated protein kinase MEK − 9.822
 HUES3 OTS-167 Maternal embryonic leucine-zipper kinase MELK − 9.707
 Jurkat BGT-226 Phosphoinositide 3-kinase P13K − 8.533
 MCF7 genz-644282 Topoisomerase I Topo I − 7.601
 A375 AS-703026 Mitogen-activated protein kinase MEK − 7.119
 MCF7 SN-38 Topoisomerase I Topo I − 6.904
 A375 SN-38 Topoisomerase I Topo I − 6.702
 HT29 TAK-733 Mitogen-activated protein kinase MEK − 6.594
 MCF7 Paclitaxel Microtubule function − 6.537
 MCF7 KX2-391 Sarcome Src − 6.366
Drugs with an increase in HPRT1 expression post treatment
 MNEU Dinaciclib Cyclin dependent kinase CDK 2.362
 NPC SB-939 Histone deacetylase HDAC 2.39
 MNEU Mitoxantrone Topoisomerase II Topo II 2.412
 NEU Ischemin P53 transcription 2.454
 ASC Mitoxantrone Inflammation 2.551
 NEU NVP-BGJ398 Fibroblast growth factor receptor FGFR 2.668
 Jurkat Tanespimycin Heat shock protein HSP 2.72
 SKL Dinaciclib Cyclin dependent kinase CDK 3.137
 ASC Dinaciclib Cyclin dependent kinase CDK 3.195
 Jurkat Dinaciclib Cyclin dependent kinase CDK 5.414
  1. PTEZ post-treatment expression z-score