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Table 1 Infrared spectrum analyses for Ros, Met, the mixture of Ros and Met, RZM

From: Rosiglitazone metformin adduct inhibits hepatocellular carcinoma proliferation via activation of AMPK/p21 pathway

Chemical bonds and functional groups Absorption peaks (cm−1)
Rosiglitazone
 C=O bonds in thiolactone and lactam 1738.37, 1694.06
 Aromatic oxide 1246.73
 =C–H bonds in benzene and pyridine ring 812.24, 763.19
 N–H bond 3416.43
Metformin
 C=NH bond 1622.80
 N–H bond 3392.57
 N–H bending vibration 1583.69, 1568.35
 Dimethyl anti-symmetric vibration 1487.91, 1475.28
 Dimethyl symmetric vibration 1448.73, 1418.94
 NH2 bond 3294.66
The mixture of rosiglitazone and metformin
 N–H bond 3372.64
 NH2 bond 3182.02
C=O bonds in thiolactone and lactam 1748.05, 1705.50
 Aromatic oxide 1253.85
 =C–H bonds in benzene and pyridine ring 823.37, 721.51
 C=NH bond 1623.37
Rosiglitazone metformin adduct
 C=O bonds in thiolactone and lactam 1676.56, 1643.85
 C=NH bond 1600.40
 NH2 bond 3185.41
 N–H bond 3386.60
 N–H bending vibration 1572.51, 1557.97
 Aromatic oxide 1243.95
 =C–H bonds in benzene and pyridine ring 824.15, 774.06