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Table 1 Infrared spectrum analyses for Ros, Met, the mixture of Ros and Met, RZM

From: Rosiglitazone metformin adduct inhibits hepatocellular carcinoma proliferation via activation of AMPK/p21 pathway

Chemical bonds and functional groups

Absorption peaks (cm−1)

Rosiglitazone

 C=O bonds in thiolactone and lactam

1738.37, 1694.06

 Aromatic oxide

1246.73

 =C–H bonds in benzene and pyridine ring

812.24, 763.19

 N–H bond

3416.43

Metformin

 C=NH bond

1622.80

 N–H bond

3392.57

 N–H bending vibration

1583.69, 1568.35

 Dimethyl anti-symmetric vibration

1487.91, 1475.28

 Dimethyl symmetric vibration

1448.73, 1418.94

 NH2 bond

3294.66

The mixture of rosiglitazone and metformin

 N–H bond

3372.64

 NH2 bond

3182.02

C=O bonds in thiolactone and lactam

1748.05, 1705.50

 Aromatic oxide

1253.85

 =C–H bonds in benzene and pyridine ring

823.37, 721.51

 C=NH bond

1623.37

Rosiglitazone metformin adduct

 C=O bonds in thiolactone and lactam

1676.56, 1643.85

 C=NH bond

1600.40

 NH2 bond

3185.41

 N–H bond

3386.60

 N–H bending vibration

1572.51, 1557.97

 Aromatic oxide

1243.95

 =C–H bonds in benzene and pyridine ring

824.15, 774.06