Rosiglitazone metformin adduct inhibits hepatocellular carcinoma proliferation via activation of AMPK/p21 pathway

Table 1 Infrared spectrum analyses for Ros, Met, the mixture of Ros and Met, RZM

Chemical bonds and functional groups	Absorption peaks (cm⁻¹)
Rosiglitazone
C=O bonds in thiolactone and lactam	1738.37, 1694.06
Aromatic oxide	1246.73
=C–H bonds in benzene and pyridine ring	812.24, 763.19
N–H bond	3416.43
Metformin
C=NH bond	1622.80
N–H bond	3392.57
N–H bending vibration	1583.69, 1568.35
Dimethyl anti-symmetric vibration	1487.91, 1475.28
Dimethyl symmetric vibration	1448.73, 1418.94
NH₂ bond	3294.66
The mixture of rosiglitazone and metformin
N–H bond	3372.64
NH₂ bond	3182.02
C=O bonds in thiolactone and lactam	1748.05, 1705.50
Aromatic oxide	1253.85
=C–H bonds in benzene and pyridine ring	823.37, 721.51
C=NH bond	1623.37
Rosiglitazone metformin adduct
C=O bonds in thiolactone and lactam	1676.56, 1643.85
C=NH bond	1600.40
NH₂ bond	3185.41
N–H bond	3386.60
N–H bending vibration	1572.51, 1557.97
Aromatic oxide	1243.95
=C–H bonds in benzene and pyridine ring	824.15, 774.06

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