From: Prognostic role of PD-L1 for HCC patients after potentially curative resection: a meta-analysis
Study | Country | Sample size | Stage | Detection method | PD-L1 + n (%) | High PD-L1 cut-off value | Tested samples | Outcome | High PD-L1 prognostic effect |
---|---|---|---|---|---|---|---|---|---|
Gao [8] | China | 240 | I–III | IHC, IPP software | 60 (25) | >75% | Tumour tissue sections | RFS; OS | Poorer significant |
Wu [11] | China | 71 | I–IV | IHC, IPP software | 35 (49) | > Median | Tumour tissues sections | OS | Poorer significant |
Umemoto [21] | Japan | 80 | I–IV | IHC, intensity of the staining scoring | 37 (46) | Score 3 | Tumour tissue sections | RFS; OS | Poorer nonsignificant |
Kan [14] | China | 128 | I–IV | IHC,positive cell rate | 105 (82) | > 25% | Tumour tissue sections | OS | Favourable significant |
Calderaro [19] | France | 217 | 0–C | IHC, positive cell rate | 36 (17) | > 1% | Tumour tissue sections | RFS | Poorer nonsignificant |
Chen [13] | China | 217 | I–III | IHC, positive cell rate | 52 (24) | > 5% | Tumour tissue sections | RFS, OS | Favourable significant |
Gabrielson [23] | USA | 58 | I–IV | IHC, intensity and distribution | 19 (32.8) | NR | Tumour tissue sections | RFS, OS | Favourable nonsignificant |
Xie [24] | China | 90 | I–III | IHC, positive cell rate | 15 (16.7) | > 5% | Tumour tissue sections | RFS, OS | Favourable nonsignificant |
Chang [7] | Korea | 146 | T1–T4 | IHC, slide scanner for positive cell rate | 80 (54.8) | Median | Tumour cell sections | RFS | Poorer significant |
Huang [20] | China | 411 | I–III | IHC, positive cell rate | 78 (19) | > 5%; | Liver cancer tissues | RFS, OS | Poorer nonsignificant |
Jung 2017 [9] | Korea | 85 | I–IV; A–D | IHC, staining percentage and intensity scoring | 23 (27) | 3–5 | Tumour cell sections | RFS, OS | Poorer significant |
Semaan [10] | Germany | 176 | T1–T4 | IHC, Tissue studio v.2.1 semiquantitative software | 88 (50) | Median | All tumour specimens | OS | Poorer significant |
Sideras 2017 [15] | Netherlands | 146 | NR | IHC, staining intensity scoring | 121 (82.9) | Cut-off with the lowest-2 log likelihood | Tumour tissue sections | RFS, OS | Favourable significant |
Chang [22] | China | 145 | NR | IHC, positive cell rate | 40 (27.6) | > 5% | Whole tissue sections | RFS, OS | Favourable nonsignificant |
Dai1 [25] | Hong Kong | 90 | NR | Staining intensity | 37 (41.1) | Score 2–3 | Tumour tissue sections | RFS, OS | Poorer significant |
Dai2 [25] | Hong Kong | 90 | NR | Staining intensity | 44 (48.89) | Score 2–3 | Tumour tissue sections | RFS, OS | Poorer significant |
Hu [26] | China | 136 | I–III | IHC, positive cell rate of membranous staining | 26 (19.1) | > 1% | Tumour tissue sections | RFS, OS | Poorer significant |
Liu [27] | China | 453 | I–KIV | IHC, positive cell rate | 87 (19.2) | ≥ 5% | Tumour tissue sections | RFS, OS | Poorer significant |