Skip to main content

Table 1 Main characteristics of the included studies

From: Prognostic role of PD-L1 for HCC patients after potentially curative resection: a meta-analysis

Study Country Sample size Stage Detection method PD-L1 + n (%) High PD-L1 cut-off value Tested samples Outcome High PD-L1 prognostic effect
Gao [8] China 240 I–III IHC, IPP software 60 (25) >75% Tumour tissue sections RFS; OS Poorer significant
Wu [11] China 71 I–IV IHC, IPP software 35 (49) > Median Tumour tissues sections OS Poorer significant
Umemoto [21] Japan 80 I–IV IHC, intensity of the staining scoring 37 (46) Score 3 Tumour tissue sections RFS; OS Poorer nonsignificant
Kan [14] China 128 I–IV IHC,positive cell rate 105 (82) > 25% Tumour tissue sections OS Favourable significant
Calderaro [19] France 217 0–C IHC, positive cell rate 36 (17) > 1% Tumour tissue sections RFS Poorer nonsignificant
Chen [13] China 217 I–III IHC, positive cell rate 52 (24) > 5% Tumour tissue sections RFS, OS Favourable significant
Gabrielson [23] USA 58 I–IV IHC, intensity and distribution 19 (32.8) NR Tumour tissue sections RFS, OS Favourable nonsignificant
Xie [24] China 90 I–III IHC, positive cell rate 15 (16.7) > 5% Tumour tissue sections RFS, OS Favourable nonsignificant
Chang [7] Korea 146 T1–T4 IHC, slide scanner for positive cell rate 80 (54.8) Median Tumour cell sections RFS Poorer significant
Huang [20] China 411 I–III IHC, positive cell rate 78 (19) > 5%; Liver cancer tissues RFS, OS Poorer nonsignificant
Jung 2017 [9] Korea 85 I–IV; A–D IHC, staining percentage and intensity scoring 23 (27) 3–5 Tumour cell sections RFS, OS Poorer significant
Semaan [10] Germany 176 T1–T4 IHC, Tissue studio v.2.1 semiquantitative software 88 (50) Median All tumour specimens OS Poorer significant
Sideras 2017 [15] Netherlands 146 NR IHC, staining intensity scoring 121 (82.9) Cut-off with the lowest-2 log likelihood Tumour tissue sections RFS, OS Favourable significant
Chang [22] China 145 NR IHC, positive cell rate 40 (27.6) > 5% Whole tissue sections RFS, OS Favourable nonsignificant
Dai1 [25] Hong Kong 90 NR Staining intensity 37 (41.1) Score 2–3 Tumour tissue sections RFS, OS Poorer significant
Dai2 [25] Hong Kong 90 NR Staining intensity 44 (48.89) Score 2–3 Tumour tissue sections RFS, OS Poorer significant
Hu [26] China 136 I–III IHC, positive cell rate of membranous staining 26 (19.1) > 1% Tumour tissue sections RFS, OS Poorer significant
Liu [27] China 453 I–KIV IHC, positive cell rate 87 (19.2) ≥ 5% Tumour tissue sections RFS, OS Poorer significant
  1. Dai et al. [25] reported data from two independent cohort. Dai1 represented data from the Prince of Wales Hospital (Hong Kong, China); Dai2 represented data from their independent validation cohort as reported
  2. HR hazard ratio, IHC immunohistochemical assay, PD-L1 programmed death ligand 1, RFS recurrence-free survival, OS overall survival