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Table 1 Main characteristics of the included studies

From: Prognostic role of PD-L1 for HCC patients after potentially curative resection: a meta-analysis

Study

Country

Sample size

Stage

Detection method

PD-L1 + n (%)

High PD-L1 cut-off value

Tested samples

Outcome

High PD-L1 prognostic effect

Gao [8]

China

240

I–III

IHC, IPP software

60 (25)

>75%

Tumour tissue sections

RFS; OS

Poorer significant

Wu [11]

China

71

I–IV

IHC, IPP software

35 (49)

> Median

Tumour tissues sections

OS

Poorer significant

Umemoto [21]

Japan

80

I–IV

IHC, intensity of the staining scoring

37 (46)

Score 3

Tumour tissue sections

RFS; OS

Poorer nonsignificant

Kan [14]

China

128

I–IV

IHC,positive cell rate

105 (82)

> 25%

Tumour tissue sections

OS

Favourable significant

Calderaro [19]

France

217

0–C

IHC, positive cell rate

36 (17)

> 1%

Tumour tissue sections

RFS

Poorer nonsignificant

Chen [13]

China

217

I–III

IHC, positive cell rate

52 (24)

> 5%

Tumour tissue sections

RFS, OS

Favourable significant

Gabrielson [23]

USA

58

I–IV

IHC, intensity and distribution

19 (32.8)

NR

Tumour tissue sections

RFS, OS

Favourable nonsignificant

Xie [24]

China

90

I–III

IHC, positive cell rate

15 (16.7)

> 5%

Tumour tissue sections

RFS, OS

Favourable nonsignificant

Chang [7]

Korea

146

T1–T4

IHC, slide scanner for positive cell rate

80 (54.8)

Median

Tumour cell sections

RFS

Poorer significant

Huang [20]

China

411

I–III

IHC, positive cell rate

78 (19)

> 5%;

Liver cancer tissues

RFS, OS

Poorer nonsignificant

Jung 2017 [9]

Korea

85

I–IV; A–D

IHC, staining percentage and intensity scoring

23 (27)

3–5

Tumour cell sections

RFS, OS

Poorer significant

Semaan [10]

Germany

176

T1–T4

IHC, Tissue studio v.2.1 semiquantitative software

88 (50)

Median

All tumour specimens

OS

Poorer significant

Sideras 2017 [15]

Netherlands

146

NR

IHC, staining intensity scoring

121 (82.9)

Cut-off with the lowest-2 log likelihood

Tumour tissue sections

RFS, OS

Favourable significant

Chang [22]

China

145

NR

IHC, positive cell rate

40 (27.6)

> 5%

Whole tissue sections

RFS, OS

Favourable nonsignificant

Dai1 [25]

Hong Kong

90

NR

Staining intensity

37 (41.1)

Score 2–3

Tumour tissue sections

RFS, OS

Poorer significant

Dai2 [25]

Hong Kong

90

NR

Staining intensity

44 (48.89)

Score 2–3

Tumour tissue sections

RFS, OS

Poorer significant

Hu [26]

China

136

I–III

IHC, positive cell rate of membranous staining

26 (19.1)

> 1%

Tumour tissue sections

RFS, OS

Poorer significant

Liu [27]

China

453

I–KIV

IHC, positive cell rate

87 (19.2)

≥ 5%

Tumour tissue sections

RFS, OS

Poorer significant

  1. Dai et al. [25] reported data from two independent cohort. Dai1 represented data from the Prince of Wales Hospital (Hong Kong, China); Dai2 represented data from their independent validation cohort as reported
  2. HR hazard ratio, IHC immunohistochemical assay, PD-L1 programmed death ligand 1, RFS recurrence-free survival, OS overall survival