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Fig. 2 | Cancer Cell International

Fig. 2

From: SOX2 interferes with the function of CDX2 in bile acid-induced gastric intestinal metaplasia

Fig. 2

Upregulation of CDX2 was sufficient to drive the activation of the intestinal phenotype. a CDX2 increased the expression of KLF4, HNF4α, and cadherin 17 at the protein and mRNA levels in GES-1 cells. b In the normal gastric cell line GES-1, ectopic expression of SOX2 failed to regulate the expression of KLF4, HNF4α, and cadherin 17 at both the protein and mRNA levels. c The expression level of CDX2 in normal gastric tissues and gastric intestinal metaplasia tissues; scale bars: 200 μm (top) and 100 μm (bottom). d qRT-PCR of CDX2 and SOX2 levels in 8 pairs of matched human IM specimens. Each symbol represents mean value of an individual patient. *P < 0.05; **P < 0.01; NS not significant (P > 0.05)

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