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Fig. 3 | Cancer Cell International

Fig. 3

From: SOX2 interferes with the function of CDX2 in bile acid-induced gastric intestinal metaplasia

Fig. 3

SOX2 interfered with CDX2 transcriptional activity in CDX2-overexpressing and bile acid-treated gastric cell lines. a, b SOX2 inhibited KLF4, HNF4α, and cadherin 17 in CDX2-overexpressing GES-1 and AGS cells. c, d SOX2 inhibited the expression of KLF4 in DCA-treated GES-1 and AGS cells. Dosage: 200 μM for 24 h. e CDX2 transcriptional response element (TRE) reporter plasmids were cotransfected with a SOX2-overexpressing plasmid and a CDX2-overexpressing plasmid or their negative controls (NCs) in HEK293T cells. *P < 0.05; **P < 0.01; NS not significant (P > 0.05)

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