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Fig. 2 | Cancer Cell International

Fig. 2

From: CIB1 depletion with docetaxel or TRAIL enhances triple-negative breast cancer cell death

Fig. 2

CIB1 depletion combined with docetaxel enhances death receptor-mediated apoptotic signaling. Docetaxel-induced caspase-8 and -3 activation is enhanced in CIB1-depleted MDA-436 but not normal ME16C cells. Control or CIB1-depleted a MDA-436 TNBC (n = 5) and b ME16C normal breast epithelial cells (n = 4) were treated with docetaxel as in Fig. 1. Lysates prepared from each cell line were probed for pro-caspase-8, cleaved caspase-8, pro-caspase-9, cleaved caspase-9, cleaved caspase-3, CIB1, and vinculin (loading control)

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