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Fig. 9 | Cancer Cell International

Fig. 9

From: Up-regulated lncRNA XIST contributes to progression of cervical cancer via regulating miR-140-5p and ORC1

Fig. 9

ORC1 was required for the XIST function in cervical cancer cell cycle. a Relative expression of ORC1 after Hela and C3AA cells transfected with si-ORC1 or empty vector. The negative effect of ORC1 downregulation on cell proliferation of Hela and C3AA cells was detected by CCK-8 assay (b, c) and EdU assay (d, e). f, g It was determined by flow cytometry that ORC1 downregulation had a suppressed effect on cell cycle of Hela and C3AA cells. And the suppressed effect was offset by miR-140-5p inhibitor or upregulation of XIST. **P < 0.01, compared with NC

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