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Table 2 Expression of candidate tumor suppressor genes in different PCa stage

From: Combined analysis and validation for DNA methylation and gene expression profiles associated with prostate cancer

Candidate tumor suppressor gene Gleason Score (GS)
GS = 6 GS = 7 GS = 8 GS = 9 GS = 10
IKZF1 No sig No sig No sig No sig Up
PPM1A No sig No sig No sig Down Down
FBP1 Up Up Up Up Down
SMCHD1 No sig Down No sig No sig Up
ALPL Down Down Down Down Down
CASP5 Down Down No sig Down No sig
PYHIN1 No sig No sig No sig No sig Up
DAPK1 Up Up Up Up Up
CASP8 No sig Up Up Up Up
  1. Up: up-regulated; down: down-regulated; no sig: no significant