Skip to main content
Fig. 5 | Cancer Cell International

Fig. 5

From: ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma

Fig. 5

BMS-509744 treatment inhibited tumor growth in a mouse xenograft model of malignant T cell lymphoma. a, b SCID mice were inoculated subcutaneously with 5 × 106 H9 cells and each group contained 8 mice. BMS-509744 (10 mg/kg, 25 mg/kg and 40 mg/kg) was administrated to the mice at the indicated concentrations once daily for 14 days when the tumor volume reached 200 mm3. The tumor volume of mice was measured every 3 days during the treatment. Statistical analysis was performed using Student’s t test. *P < 0.05, **P < 0.001 compared with control group. Data are expressed as Mean ± SEM and were derived from each treatment arm (n = 8). c Apoptosis of tumor tissue was assessed by a TUNEL assay. The nuclei were counterstained with DAPI. Representative images show apoptotic (fragmented) DNA (green staining) and the corresponding cell nuclei (blue) staining. Scale bar 20 μm. Data are expressed as Mean ± SEM

Back to article page