ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma

Table 2 Characteristics of variants identified by whole exome sequencing of TCR-related genes in 12 AITL samples

Gene	Amino acid change	Mutation type	Domain	Frequency (%)
RHOA	G17V	Missense	GTP binding	41.7
ZAP70	K333R, A601V, R175H, A76E, A475T	Missense	SH2, protein kinase	41.7
CARD11	A704V, E373Q, S904I, A701V	Missense	PDZ	33.3
CD28	D124E, T195P, R198H	Missense	Extracellular, cytoplasmic	25
FYN	T15M, D390G, A412V	Missense	SH2, protein kinase	25
LCK	R168Q, A305T, A349T, Q504H	Missense	SH2, protein kinase	33.3
PIK3CA	W824C, K1063R, Q859E, L94P	Missense		41.7
ITK	A397D, A525T	Missense	Protein kinase	16.7
KRAS	G13C, A146S	Missense	GTP binding	16.7
PIK3R1	A48V, K567E, A682V	Missense	SH3, SH2	25
VAV1	C7Y, L325P	Missense		16.7
AKT1	A409V	Missense	Protein kinase	8.3

ISSN: 1475-2867