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Fig. 4 | Cancer Cell International

Fig. 4

From: FOXD3 may be a new cellular target biomarker as a hypermethylation gene in human ovarian cancer

Fig. 4

Methylation of FOXD3 promoter and expression level in various ovarian cell. a Real-time PCR analysis showed that FOXD3 was significantly downregulated in 25 tumor tissues. b Compare to normal tissues, FOXD3 downregulation was statistically significant, *p < 0.05. c Methylation-specific PCR showed FOXD3 degree of methylation in normal tissues and tumor tissues. d Compared with that of the HOSE cell line, the FOXD3 promoter methylation degree of SKOV3, OV90 and HO8910 were significantly increased, *p < 0.05, **p < 0.01. e The results of FOXD3 mRNA expression level by Real-time PCR analysis in SKOV3, OV90 and HO8910 cell lines, *p < 0.05, compared with the HOSE cell line. f The results of FOXD3 protein expression level by western blotting in SKOV3, OV90 and HO8910 cell lines, *p < 0.05, compared with the HOSE cell line

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