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Fig. 4 | Cancer Cell International

Fig. 4

From: Contribution of voltage-gated sodium channel β-subunits to cervical cancer cells metastatic behavior

Fig. 4

Effect of NaVβs on migration and invasiveness of CeCa cells. Migration (a) and invasion (b) experiments were performed with HeLa, SiHa and CaSki cells in Boyden transwell chambers for 48 h. Bars indicate mean ± S.D. of at least three independent experiments, each performed in duplicate and presented as a percentage of control conditions. Overexpression of NaVβs in HeLa cells induced a reduction in approximately 50% in cellular migration, while the downregulation of NaVβ1 by siRNAs increased it in 58%. NaVβ1 is also involved in SiHa and CaSki migration. On the other hand, downregulation of NaVβ4 with siRNAs increased cellular invasiveness in the three cell lines. Significance: *P < 0.05, **P < 0.01

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