Table 2 Genetic variants of HOTAIR and PC risk in Stage 1
From: Functional polymorphisms in LncRNA HOTAIR contribute to susceptibility of pancreatic cancer
Genotype | Cases | Controls | Crude OR (95% CI) | Adjusted OR (95% CI)a |
|---|---|---|---|---|
rs4759314 | ||||
 AA | 327 | 354 | 1.00 (reference) | 1.00 (reference) |
 AG | 65 | 44 | 1.60 (1.06–2.41) | 1.66 (1.09–2.54) |
 GG | 8 | 2 | 4.33 (1.04–18.1) | 4.50 (1.11–18.3) |
 G vs A |  |  | 1.76 (1.22–2.55) | 1.84 (1.26–2.67) |
 P trend |  |  | 0.024 | 0.018 |
rs12427129 | ||||
 GG | 359 | 356 | 1.00 (reference) | 1.00 (reference) |
 AG | 36 | 41 | 0.87 (0.54–1.39) | 0.91 (0.66–1.25) |
 AA | 5 | 3 | 1.65 (0.4–6.87) | 1.72 (0.4–7.43) |
 A vs G |  |  | 0.98 (0.64–1.49) | 1.02 (0.76–1.35) |
 P trend |  |  | 0.564 | 0.546 |
rs200349340 | ||||
 GG | 205 | 236 | 1.00 (reference) | 1.00 (reference) |
 TG | 161 | 140 | 1.32 (0.99–1.78) | 1.38 (1.00–1.89) |
 TT | 34 | 24 | 1.63 (0.94–2.83) | 1.70 (0.96–2.99) |
 T vs G |  |  | 1.31 (1.04–1.63) | 1.36 (1.06–1.73) |
 P trend |  |  | 0.061 | 0.014 |
rs12312094 | ||||
 CC | 260 | 278 | 1.00 (reference) | 1.00 (reference) |
 CG | 128 | 116 | 1.18 (0.87–1.6) | 1.18 (0.87–1.60) |
 GG | 12 | 6 | 2.14 (0.81–5.66) | 2.13 (0.81–5.65) |
 G vs C |  |  | 1.23 (0.95–1.59) | 1.23 (0.89–1.70) |
 P trend |  |  | 0.284 | 0.214 |
rs1838169 | ||||
 CC | 269 | 275 | 1.00 (reference) | 1.00 (reference) |
 CG | 122 | 118 | 1.06 (0.78–1.43) | 1.10 (0.67–1.80) |
 GG | 9 | 7 | 1.31 (0.48–3.57) | 1.37 (0.46–4.06) |
 G vs C |  |  | 1.07 (0.83–1.39) | 1.12 (0.76–1.64) |
 P trend |  |  | 0.721 | 0.577 |
rs7958904 | ||||
 GG | 215 | 237 | 1.00 (reference) | 1.00 (reference) |
 CG | 156 | 136 | 1.26 (0.94–1.7) | 1.31 (0.94–1.82) |
 CC | 29 | 27 | 1.18 (0.68–2.06) | 1.23 (0.64–2.36) |
 C vs G |  |  | 1.17 (0.94–1.47) | 1.22 (0.93–1.59) |
 P trend |  |  | 0.119 | 0.147 |