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Table 1 Gene Ontology analysis of aberrantly methylated differentially expressed genes in prostate cancer

From: Identification of aberrantly methylated differentially expressed genes in prostate carcinoma using integrated bioinformatics

Category

Term

Count

P value

Hypomethylated with high expression

 GOTERM_BP_DIRECT

GO:0000122 —negative regulation of transcription from RNA polymerase II promoter

41

5.49E−05

 GOTERM_BP_DIRECT

GO:0001649 —osteoblast differentiation

12

1.99E−04

 GOTERM_BP_DIRECT

GO:0035556 —intracellular signal transduction

25

6.61E−04

 GOTERM_BP_DIRECT

GO:0007223 —Wnt signalling pathway, calcium-modulating pathway

7

8.00E−04

 GOTERM_BP_DIRECT

GO:0030036 —actin cytoskeleton organization

12

0.0013

 GOTERM_CC_DIRECT

GO:0005654 —nucleoplasm

111

8.73E−05

 GOTERM_CC_DIRECT

GO:0005829 —cytosol

126

1.97E−04

 GOTERM_CC_DIRECT

GO:0016604 —nuclear body

6

0.0021

 GOTERM_CC_DIRECT

GO:0005737 —cytoplasm

176

0.0030

 GOTERM_CC_DIRECT

GO:0032580 —Golgi cisterna membrane

8

0.0054

 GOTERM_MF_DIRECT

GO:0005515 —protein binding

297

2.57E−04

 GOTERM_MF_DIRECT

GO:0044212 —transcription regulatory region DNA-binding activity

16

0.0016

 GOTERM_MF_DIRECT

GO:0016874 —ligase activity

18

0.0027

 GOTERM_MF_DIRECT

GO:0005096 —GTPase activator activity

18

0.0037

 GOTERM_MF_DIRECT

GO:0003713 —transcription coactivator activity

16

0.0066

Hypermethylated with low expression

 GOTERM_BP_DIRECT

GO:0043410 —positive regulation of MAPK cascade

8

8.37E−05

 GOTERM_BP_DIRECT

GO:0006936 —muscle contraction

9

1.41E−04

 GOTERM_BP_DIRECT

GO:0007568 —ageing

11

2.19E−04

 GOTERM_BP_DIRECT

GO:0007165 —signal transduction

37

2.44E−04

 GOTERM_BP_DIRECT

GO:0014068 —positive regulation of phosphatidylinositol 3-kinase signalling

7

3.77E−04

 GOTERM_CC_DIRECT

GO:0005925 —focal adhesion

24

1.01E−03

 GOTERM_CC_DIRECT

GO:0009986 —cell surface

25

1.34E−03

 GOTERM_CC_DIRECT

GO:0070062 —extracellular exosome

74

2.77E−03

 GOTERM_CC_DIRECT

GO:0042383 —sarcolemma

9

3.60E−03

 GOTERM_CC_DIRECT

GO:0005615 —extracellular space

41

1.24E−02

 GOTERM_MF_DIRECT

GO:0003779 —actin binding

16

1.37E−04

 GOTERM_MF_DIRECT

GO:0005515 —protein binding

184

7.99E−04

 GOTERM_MF_DIRECT

GO:0030165 —PDZ domain binding

8

8.30E−04

 GOTERM_MF_DIRECT

GO:0005539 —glycosaminoglycan binding

4

0.0037

 GOTERM_MF_DIRECT

GO:0004714 —transmembrane receptor protein tyrosine kinase activity

5

0.0044