Category | Module | Score | Nodes | Enrichment and pathway description | Genes |
---|---|---|---|---|---|
Hypomethylated with high expression | 1 | 12.00 | 12 | GO:0016874—ligase activity GO:0004842—ubiquitin protein transferase activity GO:0000209—protein polyubiquitination hsa04120: ubiquitin-mediated proteolysis GO:0071377—cellular response to glucagon stimulus | TRIM36, HERC3, NEDD4L, UBE4A, CBLB, SH3RF1, ASB13, MYLIP, RNF220, UBA1, UBE2H, RBBP6 |
2 | 10.00 | 10 | GO:0007186—G-protein-coupled receptor signalling pathway GO:0007193—adenylate cyclase-inhibiting G-protein-coupled receptor signalling pathway hsa04727: GABAergic synapse | ADCY7, GNB1, GNB2, GNG7, ADCY1, DRD3, HTR1E, SST, RLN3, ADRA2A | |
3 | 8.889 | 10 | GO:0005634—nucleus GO:0005515—protein binding GO:0006260—DNA replication hsa04110: cell cycle | CENPF, E2F8, TK1, HJURP, MCM3, ZWINT, MELK, CDKN3, EXO1, CHEK1 | |
4 | 7.00 | 7 | GO:0030669—clathrin-coated endocytic vesicle membrane GO:0060071—Wnt signalling pathway, planar cell polarity pathway GO:0035615—clathrin adaptor activity hsa04144: endocytosis | FZD4, REPS2, ADRB2, SYNJ2, AP2M1, AP2A2, AAK1 | |
5 | 5.20 | 16 | GO:0006383—transcription from RNA polymerase III promoter GO:0003899—DNA-directed RNA polymerase activity GO:0032481—positive regulation of type I interferon production hsa00230: purine metabolism | POLR2D, GUCY2F, TCF7L2, POLR1D, EEF2, POLR3H, GUCY1A3, SNAPC4, TCEANC, JUP, WNT7B, CTBP1, DVL3, BRF1, CREBBP, POLR3A | |
6 | 3.444 | 19 | GO:0001649—osteoblast differentiation GO:0030206—chondroitin sulfate GO:0005515—protein binding hsa05222: focal adhesion | FHIT, COL4A1, DROSHA, NUMA1, DDX21, CMKLR1, COL3A1, DICER1, B3GALT6, OXA1L, MEF2D, FUS, DNMT3B, ARFIP2, VCAN, THBS2, CCND1, XYLT1, AKT1 | |
7 | 3.143 | 8 | GO:0009058—biosynthetic process GO:0005759—mitochondrial matrix GO:0030170—pyridoxal phosphate binding hsa01230: biosynthesis of amino acids | GPT2, FASN, GOT2, RPTOR, ATP5B, TSC2, PRDM10, SHMT2 | |
Hypermethylated with low expression | 1 | 6.00 | 13 | GO:0016032—viral process GO:0048015—phosphatidylinositol-mediated signalling GO:0061630—ubiquitin protein ligase activity hsa05200: pathways in cancer | CUL2, PIK3R1, UBE3A, PTEN, PROM1, FBXL3, KITLG, KIT, KLHL2, FBXO17, CUL1, VCAM1, UBE2V2 |
2 | 3.667 | 7 | GO:0007202—activation of phospholipase C activity GO:0010595—positive regulation of endothelial cell migration GO:0008284—positive regulation of cell proliferation | ANGPT1, FGF2, LPAR1, EDNRA, KDR, AVPR1A, CCK | |
3 | 3.333 | 7 | hsa04015: Rap1 signalling pathway GO:0045944—positive regulation of transcription from RNA Polymerase II promoter GO:0005654—nucleoplasm | HLA-F, IRF2, PPARGC1A, TRIM29, CDK8, CEBPB, KAT2B |