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Fig. 2 | Cancer Cell International

Fig. 2

From: TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response

Fig. 2

SN40R2 selected from SJSA-1 was resistant to MDM2 inhibitors and retained an NRAS mutation. a Growth inhibition curves of SJSA-1 and SN40R2 treated with MDM2 inhibitors for 72 h. b, c Immunobloting of SJSA-1 and SN40R2 treated with MDM2 inhibitors, RG7388 (a) and HDM201 (c) for 6 h. d CDKN1A, MDM2, BBC3(PUMA) and BAX expressions by qRT-PCR in SJSA-1 and SN40R2 treated with HDM201 for 6 h. e Chromatogram showing a c.181C>A NRAS mutation in both SJSA-1 and SN40R2

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Cancer Cell International

ISSN: 1475-2867

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