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Fig. 4 | Cancer Cell International

Fig. 4

From: TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response

Fig. 4

The effect of trametinib or vemurafenib treatment on cell cycle distribution and apoptosis for paired WM35 and WM35-R. Cell cycle distribution changes for 24 (a, e) and 48 (b, f) hour treatment with trametinib (a, b) or vemurafenib (e, f) by FACS analysis. Sub-G1 events by FACS (c, g) and caspase 3/7 activity (d, h), were used as indicators of apoptosis. Statistically significant p-values (*p < 0.05) are indicated. Data are presented as mean ± standard error of mean (SEM) for at least three independent repeats

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Cancer Cell International

ISSN: 1475-2867

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