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Fig. 1 | Cancer Cell International

Fig. 1

From: Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase

Fig. 1

Synergistic antiproliferative effect of capsaicin and docetaxel on prostate tumor cells. LNCaP cells (upper panel) or PC3 cells (lower panel) were incubated with increasing doses of docetaxel (DTX), capsaicin (CAP) or the combination of both compounds for 24 h and cell viability was evaluated by MTT. Data represent the mean (n = 3) ± SD. *p < 0.0001 significant difference between treated and control cells by two-way ANOVA and Dunnett’s multiple comparisons test; p < 0.0001 indicates significant interaction between DTX and CAP treatment. Data were analyzed with CompuSyn software to calculate the combination index (CI)

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