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Fig. 6 | Cancer Cell International

Fig. 6

From: Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase

Fig. 6

In vivo anti-tumor activity of Docetaxel and Capsaicin combination. Athymic nude mice were injected s.c. in the right flank with LNCaP or PC3 cells. When tumors reached a 70 mm3 size, mice were daily treated by i.p. injection with vehicle (control), 10 mg/kg Docetaxel (DTX), 2 mg/kg Capsaicin (CAP) or both compounds (DTX + CAP). Tumor volumes were measured daily. a LNCaP tumor growth curve (left) or PC3 tumor growth curve (right) after administration of vehicle (diamonds), DTX (circles), CAP (squares) or both compounds (triangles). Results represent the mean ± SEM of six mice in each group. *p < 0.05 significant difference between treated and control mice by two-way ANOVA and Tukey’s multiple comparisons test. Below is shown the tumor weight at the end of the treatment. b Immunoblot analysis of the regulatory signalling pathways in the PC3 dissected tumors

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