Fig. 2
From: Pepsin promotes IL-8 signaling-induced epithelial–mesenchymal transition in laryngeal carcinoma
Expression of IL-8 after pepsin exposure. a Change in inflammatory cytokine expression of Hep-2 and Tu212 cells exposed to different concentrations of pepsin measured using the CBA assay. Production of IL-8 and IL-6 by Hep-2 and Tu212 cells at different pepsin concentrations. b Change in inflammatory cytokine expression of Hep-2 and Tu212 cells exposed to pepsin with/without pepstatin measured using CBA assays. Production of IL-8 and IL-6 by Hep-2 and Tu212 cells at different concentrations of pepsin. c Photomicrographs representative of the immunohistochemical analyses of pepsin and IL-8 in tissue specimens from three patients with laryngeal carcinoma (magnification, ×400). *P < 0.05 compared to that of the controls