Cancer Cell International

Table 1 Association of MKP-4 expression, ERK1/2 expression and p-ERK1/2 expression with clinicopathological parameters in 160 hepatocellular carcinoma specimens

From: MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway

Parameters	Total	MKP-4 expression		P	ERK1/2 expression		P	p-ERK1/2 expression		P
Parameters	Total	Low	High	P	Low	High	P	Low	High	P
Age
≤ 45	82	66	16	0.051	24	58	0.060	36	46	0.902
> 45	78	51	27		34	44		35	43
Gender
Female	35	25	10	0.798	13	22	0.901	13	22	0.330
Male	125	92	33		45	80		58	67
Tumor differentiation
I–II	78	46	32	< 0.001*	37	41	0.004*	41	37	0.042*
III–IV	82	71	11		21	61		30	52
Tumor size
≤ 5	92	67	25	0.921	30	62	0.265	42	50	0.705
> 5	68	50	18		28	40		29	39
HBsAg
Negative	31	25	6	0.293	11	20	0.921	14	17	0.922
Positive	129	92	37		47	82		57	72
Liver cirrhosis
Negative	49	39	10	0.220	14	35	0.179	23	26	0.665
Positive	111	78	33		44	47		48	63
Tumor encapsulation
None	60	44	16	0.963	21	39	0.799	31	29	0.150
Complete	100	73	27		37	63		40	60
Child–Pugh score
A	77	58	19	0.545	31	44	0.310	36	41	0.560
B	83	59	24		27	56		35	48
Microvascular invasion
Negative	65	40	25	0.006*	30	35	0.031*	28	37	0.785
Positive	95	77	18		28	67		43	52
AFP (ng/ml)
≤ 50	122	93	29	0.112	40	82	0.103	52	70	0.424
> 50	38	24	14		18	20		19	19
TNM stage
I–II	84	54	30	0.008*	38	46	0.013*	45	39	0.014*
III–IV	76	63	13		20	56		26	50
Tumor number
Single	78	60	18	0.504	27	51	0.675	38	46	0.902
Multiple	82	57	25		31	51		20	56

Statistical analyses were performed by the Pearson χ² test
* P < 0.05 was considered significant

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ISSN: 1475-2867

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