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Table 3 Multivariate analyses of factors associated with overall survival (n = 160)

From: MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway

Variables

Hazard ratio

95% confidence interval

P value

Age (> 45 vs ≤ 45)

0.754

0.460–1.237

0.264

Gender (male vs female)

1.084

0.618–1.900

0.779

Tumor differentiation (III–IV vs I–II)

1.939

1.204–3.120

0.006*

Microvascular invasion (positive vs negative)

1.688

0.985–2.894

0.057

TNM stage (III–IV vs I–II)

0.585

0.357–0.960

0.034*

MKP-4 (low vs high)

0.175

0.086–0.355

< 0.001*

ERK1/2 (low vs high)

2.120

1.137–3.953

0.018*

p-ERK1/2 (low vs high)

2.482

1.375–4.482

0.003*

  1. Statistical analyses were performed using log-rank test
  2. * P < 0.05 was considered significant
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Cancer Cell International

ISSN: 1475-2867

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