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Table 3 Multivariate analyses of factors associated with overall survival (n = 160)

From: MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway

Variables Hazard ratio 95% confidence interval P value
Age (> 45 vs ≤ 45) 0.754 0.460–1.237 0.264
Gender (male vs female) 1.084 0.618–1.900 0.779
Tumor differentiation (III–IV vs I–II) 1.939 1.204–3.120 0.006*
Microvascular invasion (positive vs negative) 1.688 0.985–2.894 0.057
TNM stage (III–IV vs I–II) 0.585 0.357–0.960 0.034*
MKP-4 (low vs high) 0.175 0.086–0.355 < 0.001*
ERK1/2 (low vs high) 2.120 1.137–3.953 0.018*
p-ERK1/2 (low vs high) 2.482 1.375–4.482 0.003*
  1. Statistical analyses were performed using log-rank test
  2. * P < 0.05 was considered significant