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Fig. 4 | Cancer Cell International

Fig. 4

From: RETRACTED ARTICLE: LATS2 overexpression attenuates the therapeutic resistance of liver cancer HepG2 cells to sorafenib-mediated death via inhibiting the AMPK–Mfn2 signaling pathway

Fig. 4

Sorafenib-mediated mitochondrial apoptosis is augmented by LATS2 overexpression. a–e Proteins were isolated from HepG2 cells and then western blotting was used to observe the expression of mitochondria-related apoptotic proteins. f, g Immunofluorescence assay for cyt-c. The nuclear expression of cyt-c was determined to reflect the activation of mitochondrial apoptosis. Adenovirus-loaded LATS2 (Ad-LATS2) was transfected into HepG2 cells in the presence of sorafenib. h mPTP opening rate was elevated by sorafenib treatment and was further enhanced by LATS2 overexpression. i Caspase-9 activity was detected via ELISA. Adenovirus-loaded LATS2 (Ad-LATS2) was transfected into HepG2 cells in the presence of sorafenib. *p < 0.05 vs. control group; #p < 0.05 vs. Sorafenib + Ad-cont group

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Cancer Cell International

ISSN: 1475-2867

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