Fig. 2
From: Megakaryocytic dysfunction in immune thrombocytopenia is linked to autophagy
Recent evidence describing the pathogenesis of autophagy in ITP. Lineage-specific deletion of ATG in haematopoietic stem cells (HSCs) impairs megakaryopoiesis in the bone marrow. The enhanced expression of mTOR on the surface of megakaryocytes decreases the extent of autophagy. A close connection between the above steps leads to fewer platelet counts in the bone marrow and peripheral blood, as well as abnormal haemostasis