Fig. 4
SNHG12 deficiency suppressed xenograft tumor growth in vivo. a The stable SNHG12-deficient Caki-1 cell line was established and subcutaneously inoculated into nude mice. The xenograft tumors were weighed after sacrifice, ****p < 0.0001. b Macroscopic images of representative xenograft tumors from both control and shSNHG12 mice resected at week 5 post-inoculation. c The tumor growth was monitored by digital caliper at day 0, 7, 14, 21, 28 and 35 post-injection respectively and the volume was calculated with the formula: volume = (width)2 × length/2. Ns, no significance, ****p < 0.0001. d The persistent silencing of SNHG12 in xenograft tumor was confirmed by real-time PCR. **p < 0.01