Table 3 Subgroup and meta-regression analyses for OS in this meta-analysis
From: The prognostic value of serum amyloid A in solid tumors: a meta-analysis
Subgroup | No. of studies | No. of patients | Fixed-effects model | Meta-regression | Heterogeneity | ||
|---|---|---|---|---|---|---|---|
HR (95% CI) | P-value | P value | I2 (%) | P-value | |||
All | 12 | 2749 | 3.01 (1.96–4.63) | < 0.01 | 82.7 | 0.00 | |
Tumor types | 0.30 | ||||||
Urinary system cancer | 3 | 305 | 2.31 (1.54–3.48) | < 0.01 | 0.0 | 0.42 | |
Digestive system cancer | 6 | 1177 | 3.97 (1.98–7.94) | < 0.01 | 82.3 | 0.00 | |
Other system cancer | 3 | 1267 | 1.70 (1.34–2.16) | < 0.01 | 57.9 | 0.09 | |
Detection methods | 0.24 | ||||||
LTIA | 2 | 187 | 4.15 (1.65–10.43) | < 0.01 | 0.0 | 0.61 | |
Nephelometry | 6 | 1587 | 3.75 (1.97–7.14) | < 0.01 | 84.5 | 0.00 | |
ELISA | 4 | 975 | 1.69 (1.35–2.11) | < 0.01 | 11.2 | 0.34 | |
Cut-off values (mg/l) | 0.03 | ||||||
≤ 5.3 | 6 | 1346 | 1.80 (1.47–2.20) | < 0.01 | 7.9 | 0.37 | |
> 5.3 | 5 | 1284 | 4.87 (2.32–10.26) | < 0.01 | 81.1 | 0.00 | |
Sample sizes | 0.16 | ||||||
≤ 143 | 6 | 593 | 1.77 (1.42–2.20) | < 0.01 | 25.0 | 0.25 | |
> 143 | 6 | 2156 | 3.82 (2.01–7.25) | < 0.01 | 84.4 | 0.00 | |
Areas | 0.26 | ||||||
Asian countries | 7 | 1467 | 3.78 (1.72–8.32) | < 0.01 | 90.3 | 0.00 | |
Non-Asian countries | 5 | 1282 | 2.30 (1.76–3.00) | < 0.01 | 0.0 | 0.91 | |
Variance analyses | 0.46 | ||||||
Multivariate | 9 | 1943 | 3.32 (1.91–5.77) | < 0.01 | 87.3 | 0.00 | |
Univariate | 3 | 806 | 2.27 (1.50–3.45) | < 0.01 | 0.0 | 0.84 | |