Table 4 Subgroup analyses of NLR for OS and PFS

Ethnicity

 Asian

1.52–2.21

0.000

0.0%

0.715

5

1.59

1.23–2.06

0.000

0.0%

0.436

 Other

1.26–1.66

0.000

86.6%

0.000

7

1.62

1.18–2.23

0.003

79.7%

0.000

Patients status

 mCRPC

1.52–1.90

0.000

17.7%

0.265

6

1.62

1.33–1.98

0.000

45.3%

0.140

 CRPC

1.40–2.48

0.000

0.0%

0.716

4

1.76

1.18–2.62

0.006

28.5%

0.221

 Localized PCa

0.93–1.31

0.274

71.7%

0.029

1

3.09

1.64–5.82

0.000

–

–

 All PCa

1.02–1.41

0.026

53.5%

0.072

1

0.84

0.74–1.19

0.603

–

–

Sample size

 ≤ 300

1.40–2.16

0.002

59.6%

0.598

9

1.51

1.13–2.01

0.005

58.7%

0.013

 > 300

1.23–1.71

0.000

89.5%

0.000

3

1.88

1.32–2.67

0.000

73.5%

0.023

Follow time

 ≤ 30

1.55–1.95

0.000

0.0%

0.748

7

1.77

1.39–2.27

0.000

45.3%

0.089

 > 30

1.02–1.30

0.020

75.2%

0.000

3

1.59

0.77–3.28

0.212

84.8%

0.001

 Unclear

1.39–1.80

0.000

0.0%

0.430

2

1.36

1.00–1.88

0.061

0.0%

0.700

Cut-off

 ≤ 3

1.57–1.97

0.000

0.0%

0.014

5

1.81

1.36–2.42

0.000

51.2%

0.085

 > 3

1.32–2.00

0.000

53.8%

0.444

7

1.50

1.09–2.07

0.014

68.5%

0.004

 No

0.97–1.34

0.101

88.5%

0.000

0

–

–

–

–

–

Study design

 Retrospective

1.39–1.91

0.000

84.0%

0.000

9

1.74

1.42–2.13

0.000

25.3%

0.219

 Prospective

1.10–1.68

0.005

66.7%

0.017

3

1.42

0.89–2.26

0.144

84.3%

0.002

Statistical method

 Multivariable

1.34–1.77

0.000

79.5%

0.000

10

1.65

1.22–2.24

0.001

66.3%

0.002

 Univariable

1.17–2.10

0.003

85.9%

0.000

2

1.66

1.20–2.30

0.002

74.1%

0.049

Therapy

 Surgery

0.99–1.26

0.072

72.7%

0.005

2

1.64

0.51–5.26

0.404

91.6%

0.001

 Chemotherapy

1.53–1.84

0.000

1.2%

0.440

10

1.64

1.38–1.95

0.000

27.8%

0.188

 Radiotherapy

0.95–1.27

0.198

–

–

–

–

–

–

–

–

 Others

1.07–2.47

0.022

0.0%

0.638

–

–

–

–

–

–