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Fig. 5 | Cancer Cell International

Fig. 5

From: Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells

Fig. 5

The effect of lycopene on the expression of IFNγ related genes in LLC cells. The IFN-related gene expressions were measured by qRT-PCR, and the protein expression of IRF1, IRF7 were measured by Western blot (a–d). After the treatment of lycopene, the change of methylation status of IRF1/7 promoter regions were assessed by bisulfite sequencing analysis, (black circle, methylated cytosine of CpG; white circle, unmethylated cytosine of CpG) (e). The expressions of DNMT1, DNMT3A, and DNMT3B in LLC cells were analyzed by Western blot (f, g). *p < 0.05 vs. control

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Cancer Cell International

ISSN: 1475-2867

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