Fig. 6From: Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cellsThe effect and mechanism of lycopene on the expression of PDL-1 downstream the IFNγ signaling. The mRNA and protein expression of PDL-1 in tumor were detected by qRt-PCR and Western blot (a, b). Lycopene inhibited the increased expression of PD-L1 induced by IFNγ in LLC cells (c, d), *p < 0.05 vs. control, #p < 0.05 vs. IFNγ (n = 6). Lycopene activated the JAK2 signal and inhibited AKT signaling to repress expression of PD-L1 in LLC cells (e, f), *p < 0.05 vs. control (n = 6)Back to article page