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Fig. 6 | Cancer Cell International

Fig. 6

From: Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells

Fig. 6

The effect and mechanism of lycopene on the expression of PDL-1 downstream the IFNγ signaling. The mRNA and protein expression of PDL-1 in tumor were detected by qRt-PCR and Western blot (a, b). Lycopene inhibited the increased expression of PD-L1 induced by IFNγ in LLC cells (c, d), *p < 0.05 vs. control, #p < 0.05 vs. IFNγ (n = 6). Lycopene activated the JAK2 signal and inhibited AKT signaling to repress expression of PD-L1 in LLC cells (e, f), *p < 0.05 vs. control (n = 6)

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