Fig. 2

Diagrams depicting the sorting process of genes to identify gene-expression based survival markers based on diagnostic age. a Filter 1 indicates genes that were significantly upregulated in either older (top) or younger (bottom) patients, Pearson Correlation Coefficient, p-value < 0.05. Filter 2 indicates genes that were significantly correlated with either low (top) or high (bottom) survival, log-transformed t-test p-value < 0.05. b Filter 3 indicates genes that were also low (top) or high (bottom) survival markers, when upregulated, within the oldest 20% of patients. Finally, Filter 4 indicates genes that were also low (top) or high (bottom) survival markers, when upregulated, within the youngest 20% of patients. The right-most boxes indicate the number of genes that cleared all four filters, indicating the upregulated genes that are indicative of older age and lower survival (2 genes) as well as the upregulated genes indicative of younger age and higher survival (4 genes)