Fig. 5From: PITX2 enhances progression of lung adenocarcinoma by transcriptionally regulating WNT3A and activating Wnt/β-catenin signaling pathwayKnockdown of PITX2 inhibited proliferation of LUAD in vivo. a The tumor xenografts were excised and representative images were shown. b, c Knockdown of PITX2 suppressed tumor growth and decreased tumor weight in nude mice (n = 6 per group). d Immunohistochemical staining showed that knockdown of PITX2 reduced the expression of WNT3A, CyclinD1 and C-Myc (*p < 0.05, **p < 0.01, ***p < 0.001)Back to article page