TY - JOUR AU - Yan, Wenzhe AU - Li, Ji AU - Zhang, Yang AU - Yin, Yafei AU - Cheng, Zhao AU - Wang, Jiayi AU - Hu, Guoyu AU - Liu, Sufang AU - Wang, Yewei AU - Xu, Yunxiao AU - Peng, Hongling AU - Zhang, Guangsen PY - 2019 DA - 2019/04/04 TI - RNF8 is responsible for ATRA resistance in variant acute promyelocytic leukemia with GTF2I/RARA fusion, and inhibition of the ubiquitin–proteasome pathway contributes to the reversion of ATRA resistance JO - Cancer Cell International SP - 84 VL - 19 IS - 1 AB - GTF2I-RARA is a newly identified RARA fusion gene in variant acute promyelocytic leukemia (APL) patients with t(7;17)(q11;q21). Clinical manifestation in the patient showed that it is a sort of ATRA-insensitive oncogene and is different from the classic PML-RARA in terms of therapeutic reaction. SN - 1475-2867 UR - https://doi.org/10.1186/s12935-019-0803-4 DO - 10.1186/s12935-019-0803-4 ID - Yan2019 ER -