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Fig. 3 | Cancer Cell International

Fig. 3

From: RNF8 is responsible for ATRA resistance in variant acute promyelocytic leukemia with GTF2I/RARA fusion, and inhibition of the ubiquitin–proteasome pathway contributes to the reversion of ATRA resistance

Fig. 3

Genome-wide analysis of the GTF2I-RARA binding components in transfected HL60 cells. Binding components of GTF2I-RARA were determined using ChIP-seq. a Genome-wide distributions of GTF2I-RARA binding sites. b Distribution of binding sites of GTF2I-RARA is shown as a bar graph. c De novo motif logo for the top-ranking motif identified by Multiple EM for Motif Elicitation software when searching from the GTF2I-RARA binding sites. d Analysis of mRNA expression of potential target genes in GTF2I-RARA-transfected and control HL60 cells. e Western blot results for candidate targeting genes in GTF2I-RARA-transfected and control HL60 cells. **p < 0.01

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Cancer Cell International

ISSN: 1475-2867

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