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Fig. 1 | Cancer Cell International

Fig. 1

From: Systems biology based meth-miRNA–mRNA regulatory network identifies metabolic imbalance and hyperactive cell cycle signaling involved in hepatocellular carcinoma onset and progression

Fig. 1

Metabolic signaling enriched meth-miRNA–mRNA network of tumor suppressor genes in HCC. Graphs showing top 10 KEGG pathways and functional annotation GO terms associated with potential tumor suppressors (a). Venn diagrams showing number of shared tumor suppressor targets of top 5 oncogenic miRNAs (top) and number of shared tumor suppressors whose expression can either be modulated by gene hypermethylation and/or due to targeting by oncogenic miRNAs in TS-mRNA-GS (bottom) (b). meth-miRNA–mRNA network showing tumor suppressors being targeted by oncogenic miRNAs. Rectangles indicate genes/mRNAs and hexagons indicate miRNAs. Red represents high expression and green represents low expression in HCC as compared to adjacent normal tissues. Genes whose expressions are found to be down-regulated due to gene hyper-methylation in HCC are shown with yellow border (c)

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