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Fig. 2 | Cancer Cell International

Fig. 2

From: Systems biology based meth-miRNA–mRNA regulatory network identifies metabolic imbalance and hyperactive cell cycle signaling involved in hepatocellular carcinoma onset and progression

Fig. 2

Cell cycle signaling enriched meth-miRNA–mRNA network of oncogenes in HCC. Graphs showing top 10 KEGG pathways and functional annotation GO terms associated with potential oncogenes (a). Venn diagrams showing number of shared oncogenic targets of top 5 tumor suppressor miRNAs (top) and number of shared oncogenes whose expression can either be modulated by gene hypo-methylation and/or due to targeting by tumor suppressor miRNAs in OG-mRNA-GS (bottom) (b). meth-miRNA–mRNA network showing oncogenes being targeted by tumor suppressor miRNAs. Rectangles indicate genes/mRNAs and hexagons indicate miRNAs. Red represents high expression and green represents low expression in HCC as compared to adjacent normal tissues. Genes whose expressions are found to be up-regulated due to gene hypo-methylation in HCC are shown with blue border (c)

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