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Fig. 3 | Cancer Cell International

Fig. 3

From: Systems biology based meth-miRNA–mRNA regulatory network identifies metabolic imbalance and hyperactive cell cycle signaling involved in hepatocellular carcinoma onset and progression

Fig. 3

Metabolic imbalance and hyperactive cell cycle signaling are key features of HCC onset and progression. Heatmap showing enrichment of already published metabolic pathways associated gene sets (n = 14) and cell cycle signaling associated gene sets (n = 14) in HCC tissues and adjacent normal tissues of patients from 10 different GEO datasets (a). Heatmap showing correlation analyses of Z-scores of already published metabolic pathways associated gene sets (n = 14) and cell cycle signaling associated gene sets (n = 14) with our TS-mRNA-GS and OG-mRNA-GS scores (b). Heatmap showing enrichment of TS-mRNA-GS and OG-mRNA-GS in HCC tissues and adjacent normal tissues of patients from 10 different GEO datasets (c)

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Cancer Cell International

ISSN: 1475-2867

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