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Fig. 5 | Cancer Cell International

Fig. 5

From: Systems biology based meth-miRNA–mRNA regulatory network identifies metabolic imbalance and hyperactive cell cycle signaling involved in hepatocellular carcinoma onset and progression

Fig. 5

miRNA-GS is associated with less aggressive state and good survival in HCC patients. Scatter-plot showing correlation analysis between miRNA expression score and their targets’ expression score for OG-miRNA-GS (a) and TS-miRNA-GS (b) in HCC patients from TCGA database (n = 368). Dot-plot showing miRNA-GS-score in HCC patients who experienced or did not experience vascular invasion in GEO dataset GSE67140 (c). Kaplan–Meier survival plots representing the percentage overall survival in HCC patients from GSE31384 (n = 216) (d) and from TCGA database (n = 370) (e) based on low vs high miRNA-GS score. Kaplan–Meier survival plots representing the percentage relapse free survival in HCC patients from and TCGA database (n = 319) based on low vs high miRNA-GS score (f). *p < 0.05; **p < 0.01; ns, not significant, Student’s t-test

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Cancer Cell International

ISSN: 1475-2867

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