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Fig. 6 | Cancer Cell International

Fig. 6

From: Systems biology based meth-miRNA–mRNA regulatory network identifies metabolic imbalance and hyperactive cell cycle signaling involved in hepatocellular carcinoma onset and progression

Fig. 6

mRNA-GS is associated with less aggressive state and good survival in HCC patients. Gene set enrichment plots of HCC patients from GSE62043 (n = 100) with low or high mRNA-GS score. Genes down-regulated in tumor compared to non-tumor liver samples from patients with HCC (a) and top 200 marker genes down-regulated in the ‘proliferation’ subclass of HCC; characterized by increased proliferation, high levels of serum AFP, and chromosomal instability, are enriched in patients having high mRNA-GS scores (b) whereas top 200 marker genes up-regulated in the ‘proliferation’ subclass of HCC are enriched in patients having low mRNA-GS score (c). Dot-plot showing mRNA-GS scores in HCC patients having good, intermediate or poor prognosis in GEO dataset GSE15654 (d). Gene set enrichment plots of HCC patients from GSE62043 (n = 100) with low or high mRNA-GS score. Genes whose expressions are correlated with good survival of HCC patients (e) and genes whose expressions are correlated with lower risk of late recurrence in HCC (f) are enriched in patients having high mRNA-GS score. Kaplan–Meier survival plots representing the percentage overall survival in HCC patients from GSE15654 (n = 216) (g) and from TCGA database (n = 370) (h) based on low vs high mRNA-GS score. Kaplan–Meier survival plots representing the percentage relapse free survival in HCC patients from and TCGA database (n = 319) based on low vs high mRNA-GS score (i)

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