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Fig. 2 | Cancer Cell International

Fig. 2

From: Cross-talk between ER stress and mitochondrial pathway mediated adriamycin-induced testicular toxicity and DA-9401 modulate adriamycin-induced apoptosis in Sprague–Dawley rats

Fig. 2

Effect of DA-9401 on testicular protein levels in adriamycin (ADR) treated male SD rats determined by western blot analysis. a GRP-78, b p-JNK, c p-IRE, d Pro-caspase-3, e Cleaved caspase-3, f Bax/Bcl2 ratio, g Claudin 11, h Occludin, i ZO1, j StAR, k GSK3, l CatSper. Results are expressed as mean ± SEM. CTR, Control; DA 100, DA-9401 100 mg/kg/day p.o.; ADR, Adriamycin 2 mg/kg i.p. per week; ADR + DA 100, Adriamycin 2 mg/kg i.p. per week + DA-9401 100 mg/kg/day p.o.; ADR + DA 200, Adriamycin 2 mg/kg i.p. per week + DA-9401 200 mg/kg/day p.o.; GRP-78, Glucose regulated protein-78; p-JNK, Phosphorylated c-jun-N-terminal kinase; p-IRE1α, Phosphorylated Inositol-Requiring Transmembrane Kinase/Endoribonuclease 1α; Bax, BCL 2 associated X protein; Bcl-2, B-cell lymphoma 2; ZO1, Zonula occludens-1; StAR, Steroidogenic acute regulatory protein; GSK-3α, Glycogen synthase kinase 3α; CatSper, Cation channels of sperm; p.o., Per oral; i.p., Intraperitoneally. *P < 0.05 vs. CTR group,#P < 0.05 vs. DA 100 group, +P < 0.05 vs. ADR group, $P < 0.05 vs. ADR + DA 100 group (one-way ANOVA followed by Tukey’s post hoc test; n = 10 for each group)

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