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Table 1 Growth inhibition of Bufalin (BF) on human cancer cell lines after 24–72H treatment

From: New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin

Cancer type Cell line 24H IC50 48H IC50 72H IC50 Refs.
Breast MCF-7 317.9 ± 1.5 nM 46.5 ± 1.4 nM   Yan et al. [125]
3.2 nM    Wang et al. [56]
MCF-7/ADR   100.17 ± 30.16 nmol/L   Wang et al. [126]
MCF-10A 465.2 ± 25.9 nM    Clifford et al. [31]
MCF10CA1 635.2 ± 171.8 nM    Clifford et al. [31]
MDA-MB-231 934.1 ± 2.0 nM 513.3 ± 1.6 nM   Yan et al. [125]
  263.3 ± 68.24 nmol/L   Wang et al. [126]
936.4 ± 4.9 nM    Clifford et al. [31]
   20.0 nM Song et al. [55]
MDA-MB-231-LM3-3    16.6 nM Song et al. [55]
SUM149PT    16.6 nM Song et al. [55]
SUM159PT    15.9 nM Song et al. [55]
Cervical Hela 154 ± 21.5 nM 37.5 ± 2.15 nM 11.8 ± 2.13 nM Pan et al. [127]
Colorectal SW620 76.72 ± 6.21 nmol/L 34.05 ± 4.21 nmol/L 16.7 ± 6.37 nmol/L Zhu et al. [128]
287.35 ± 4.34 nM 57.63 ± 7.80 nM 20.39 ± 1.95 nM Zhang et al. [129]
HCT116 82.6 μmol/L    Qiu et al. [130]
0.243 μM 0.024 μM   Wang et al. [131]
LoVo 56.778 ± 7.34 nM 11.48 ± 2.89 nM 6.64 ± 2.79 nM Zhang et al. [129]
Endometrial Ishikawa   0.7 ng/mL   Takai et al. [132]
HHUA   0.5 ng/mL   Takai et al. [132]
HEC-1B   0.6 ng/mL   Takai et al. [132]
Esophageal Eca-109    1.0 μM Lv et al. [133]
EC9706    1.0 μM Lv et al. [133]
TE5    2.6 μM Lv et al. [133]
TE11    4.9 μM Lv et al. [133]
Hec2    3.8 μM Lv et al. [133]
Gallbladder GBC-SD   48.12 ± 2.03 nM 28.23 ± 1.78 nM Jiang et al. [45]
SGC996   125.03 ± 5.16 nM 102.78 ± 3.21 nM Jiang et al. [45]
Gastric SGC7901 > 800 nmol/L    Li et al. [134]
MGC803 160 ± 0.87 nmol/L    Li et al. [134]
Liver HepG2 182.30 ± 13.78 nM    Li et al. [27]
307 ± 87 nM    Ozdemir et al. [84]
  33.65 nmol/L   Gao et al. [60]
  143.2 nM   Miao et al. [49]
PLC/PRF/5 52.20 ± 14.16 nM    Li et al. [27]
  157.87 nmol/L   Gao et al. [60]
SMMC7721 97.74 ± 8.83 nM    Li et al. [27]
SK-HEP-1 110.33 ± 5.32 nM    Tsai et al. [135]
Leukemia NB4 40 nmol/L 27 nmol/L 17 nmol/L Zhai et al. [136]
K562    0.0943 μmol/L Zhai et al. [136]
K562/VCR    0.0401 μmol/L Zhai et al. [136]
HEL   0.046 μmol/L   Wang et al. [137]
Lung A549 4.5 nM    Wang et al. [56]
  56.14 ± 6.72 nmol/L 15.57 ± 4.28 nmol/L Zhu et al. [138]
   8.15 ± 0.69 nmol/L Sun et al. [92]
22.00 ± 3.53 nM 10.20 ± 1.01 nM   Liu et al. [36]
Melanoma A375.S2   450.38 nM   Hsiao et al. [44]
Oral CAL27 125 nM    Tsai et al. [139]
122.6 nM    Tian et al. [140]
Osteosarcoma U-2OS 0.297 μM    Zhang et al. [141]
  8.49 ± 2.1 μg/L   Yin et al. [142]
U-2OS/MTX300   10.19 ± 1.7 μg/L   Yin et al. [142]
Saos-2 0.318 μΜ    Zhang et al. [141]
Ovarian SK-OV-3   1.0 ng/mL   Takai et al. [132]
OMC-3   0.6 ng/mL   Takai et al. [132]
Tongue SCC-4   300 nM   Chou et al. [143]
Pancreatic Capan-2 159.2 nM    Tian et al. [140]
Non-cancerous Breast epithelial cell 184D 384.6 ± 36.5 nM    Clifford et al. [31]
Breast epithelial cell 184A 295.9 ± 10.5 nM    Clifford et al. [31]
Mouse normal hepatocyte    No cytotoxicity at 10 μM Song et al. [55]
HUVECs 53.1 nmol/L    Qiu et al. [130]
Het-1Aa    10.1 μM Lv et al. [133]
PBMCsb   16.5 ± 4.7 ng/mL   Yuan et al. [144]
Primary normal human endometrial epithelial cells   Little sensitivity to BF from 0.1 to 10 ng/mL   Takai et al. [132]
PBMCs   16.5 ± 4.7 ng/mL   Yuan et al. [144]
  1. aHuman normal esophageal squamous cells
  2. bNormal peripheral blood mononuclear cells (PBMCs) were isolated from three healthy volunteers (32 ± 9 years of age)