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Fig. 6 | Cancer Cell International

Fig. 6

From: Silencing long non-coding RNA HOTAIR exerts anti-oncogenic effect on human acute myeloid leukemia via demethylation of HOXA5 by inhibiting Dnmt3b

Fig. 6

The molecular mechanism that HOTAIR affected the progression of AMI by regulating HOXA5. LncRNA HOTAIR promotes HOXA5 promoter methylation by recruiting Dnmt3b to inhibit expression of HOXA5, thereby promoting the proliferation and inhibiting apoptosis of AML cells. However, silenced could reverse the above development, thus protecting against the deterioration of AML. HOTAIR Hox transcript antisense intergenic RNA, AML acute myeloid leukemia, HOXA5 homeobox A5, Dnmt3b DNA methyltransferase 3b

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Cancer Cell International

ISSN: 1475-2867

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