Fig. 4From: Genetic variants in the circadian rhythm pathway as indicators of prostate cancer progressionNegative correlation of NPAS2 mRNA expression with prostate cancer progression. The associations between NPAS2 expression and prostate cancer aggressiveness were analysed using data of the MSKCC Prostate Oncogenome Project. More advanced prostate cancers, pathologic stage T3/T4 vs. T2 (a), and pathologic Gleason score ≥ 7 vs. < 7 (b) were associated with significantly lower mRNA expression levels of NPAS2. c Kaplan–Meier curves of biochemical recurrence (BCR)-free survival according to the expression of NPAS2. Patients were dichotomized based on the median expression level of NPAS2Back to article page