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Fig. 4 | Cancer Cell International

Fig. 4

From: Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway

Fig. 4

5-FU-activated mitochondrial apoptosis could be enhanced by LATS2 overexpression. a, b The levels of ROS were evaluated via flow cytometry. c, d Immunofluorescence assay for cyt-c translocation. The expression of nuclear cyt-c was determined to quantify mitochondrial apoptosis. ei Proteins were isolated from SW480 cells and then the expression of mitochondrial apoptotic factors was evaluated via western blotting. *p < 0.05 vs. control (ctrl) group; #p < 0.05 vs. 5-FU + ad-ctrl group; ad-ctrl: control null adenovirus vectors; ad-LATS2: LATS2 adenovirus vectors

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