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Fig. 7 | Cancer Cell International

Fig. 7

From: Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway

Fig. 7

5-FU/LATS2 controls MIEF1 expression via the JNK pathway. ac SW480 cells were treated with 5-FU and/or transfected with LATS2 adenovirus. SP600125 was used to inhibit the JNK activation. Proteins were isolated from SW480 cells and then the expression of p-JNK and MIEF1 was determined via western blotting. df Immunofluorescence assay for p-JNK and MIEF1. The fluorescence intensity of p-JNK and MIEF1 was determined. SP600125 was used to inhibit the JNK activation. *p < 0.05 vs. control (ctrl) group; #p < 0.05 vs. 5-FU + ad-ctrl group; @p < 0.05 vs.5-FU + ad-LATS2; ad-ctrl: control null adenovirus vectors; ad-LATS2: LATS2 adenovirus vectors

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