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Fig. 4 | Cancer Cell International

Fig. 4

From: Overexpression of HHLA2 in human clear cell renal cell carcinoma is significantly associated with poor survival of the patients

Fig. 4

Expressions of Cyclin D1, c-Myc and Cyclin E1 in ccRCC cell lines after knockdown of HHLA2. ac The knockdown HHLA2 expression significantly increased the ratio of G1 phase and induced cell cycle arrest in human ccRCC cell lines. d Western blotting analysis of Cyclin D1, c-Myc and Cyclin E1 in ccRCC cell lines after knockdown of HHLA2 expression in 786-O and ACHN cells respectively. e The Cyclin D1 was significantly decreased in the LV-HHLA2-sh1 (P < 0.01 in 786-O cells, and P < 0.01 in ACHN cells) and LV-HHLA2-sh2 (P < 0.01 in 786-O cells, and P < 0.01 in ACHN cells) compared with the LV-NC group cells. f The c-Myc was significantly decreased in the LV-HHLA2-sh1 (P < 0.01 in 786-O cells, and P < 0.01 in ACHN cells) and LV-HHLA2-sh2 (P < 0.01 in 786-O cells, and P < 0.001 in ACHN cells) compared with the LV-NC group cells. g The Cyclin E1 was significantly decreased in the LV-HHLA2-sh1 (P < 0.0001 in 786-O cells, and P < 0.0001 in ACHN cells) and LV-HHLA2-sh2 (P < 0.0001 in 786-O cells, and P < 0.01 in ACHN cells) compared with the LV-NC group cells

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