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Table 1 Selected substrates and inhibitors of P-gp/ABCB1, MRP/ABCC1, and BCRP/ABCG2 as chemosensitizers

From: The role of photodynamic therapy on multidrug resistant breast cancer

Efflux protein transporters Substrate Inhibitors References
P-gp/ABCB1 5-Fluorouracil, doxorubicin, paclitaxel, vincristine, vinblastine, vindesine, vinorelbine, mitoxantrone, topotecan, actinomycin D Cyclosporin A, quinine, verapamil, valspodar, tariquidar, zosuquidar, laniquidar, dexverapamil, nifedipine, quinidine, chlorpromazine [39, 45, 93, 96, 97]
MRP/ABCC1 Daunorubicin, imatinib, doxorubicin, melphalan, chlorambucil, saquinivir, vincristine, irinotecan, ciprofloxacin, mitoxantrone Biricodar/VX-710, cyclosporine A, efavirenz elacridar/GG918/GF120918, verapamil, agosterol A, curcumin, disulfiram, flavonoids, clotrimazole, steroid analogues, probenecid [53, 96, 98,99,100]
BCRP/ABCG2 Mitoxantrone, camptothecin derivatives, methotrexate, lamivudine, prazosin, cimetidine, nilotinib, nitrofurantoin, flavopiridol, gefitinib Cyclosporine A, sirolimus, tamoxifen, omeprazole, piperine, novobiocin, dofequidar, nelfinavir, boceprevir, fluconazole, dipyridamole [35, 96]
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