Table 1 Selected substrates and inhibitors of P-gp/ABCB1, MRP/ABCC1, and BCRP/ABCG2 as chemosensitizers
From: The role of photodynamic therapy on multidrug resistant breast cancer
Efflux protein transporters | Substrate | Inhibitors | References |
|---|---|---|---|
P-gp/ABCB1 | 5-Fluorouracil, doxorubicin, paclitaxel, vincristine, vinblastine, vindesine, vinorelbine, mitoxantrone, topotecan, actinomycin D | Cyclosporin A, quinine, verapamil, valspodar, tariquidar, zosuquidar, laniquidar, dexverapamil, nifedipine, quinidine, chlorpromazine | |
MRP/ABCC1 | Daunorubicin, imatinib, doxorubicin, melphalan, chlorambucil, saquinivir, vincristine, irinotecan, ciprofloxacin, mitoxantrone | Biricodar/VX-710, cyclosporine A, efavirenz elacridar/GG918/GF120918, verapamil, agosterol A, curcumin, disulfiram, flavonoids, clotrimazole, steroid analogues, probenecid | |
BCRP/ABCG2 | Mitoxantrone, camptothecin derivatives, methotrexate, lamivudine, prazosin, cimetidine, nilotinib, nitrofurantoin, flavopiridol, gefitinib | Cyclosporine A, sirolimus, tamoxifen, omeprazole, piperine, novobiocin, dofequidar, nelfinavir, boceprevir, fluconazole, dipyridamole |