TY - JOUR AU - Wu, Zhiqiang AU - Qiu, Minghan AU - Guo, Yu AU - Zhao, Jinlin AU - Liu, Zhuang AU - Wang, Hui AU - Meng, Maobin AU - Yuan, Zhiyong AU - Mi, Zeyun PY - 2019 DA - 2019/04/15 TI - OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair JO - Cancer Cell International SP - 99 VL - 19 IS - 1 AB - Radiotherapy is becoming one major therapeutics for non-small cell lung cancer (NSCLC). Identifying novel radiosensitizers will greatly increase the efficacy of radiotherapy and benefit more patients. OTU deubiquitinase 4 (OTUD4) has been reported involved in DNA damage repair pathways and could be a potential target for chemotherapy therapy. This study aimed to investigate the roles of OTUD4 in regulation of radiosensitivity of NSCLC via modulating DNA repair. SN - 1475-2867 UR - https://doi.org/10.1186/s12935-019-0816-z DO - 10.1186/s12935-019-0816-z ID - Wu2019 ER -